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I don't have this problem at the moment, knock on wood, but the Renegade is my first 4WD car and I was wondering what the tread tolerances are on it for replacing a single tire in case of a flat? I know most AWD systems are sensitive to 2/32 vs 1/4 in. just curious if the Jeep 4WD system is also sensitive to 2/32 or if there's some other tolerance?

As long as it is the same size tire, it is OK. A sensitivity of 1/16" is ridiculous. You get more than that if one tire is a few pounds low on air pressure. You can have a a 1/2" difference and be good.